Stylus Magazine weighs in with their top 50 singles of 2005. This list is much more comprehensive than any that I could come up with since it embraces so many different genres. From their selections that jibe with my musical tastes though, it sounds pretty accurate.
The real question now is, with the continued rise of electronic music downloads (legal or otherwise), how relevant is the single anymore?
NP: "Gods Will Be Gods" - Echo & the Bunnymen